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Lipolysis of emulsion models of triglyceride-rich lipoproteins is altered in male patients with abdominal aorta aneurysm
Hosni, J. J; Vinagre, C. G; Mady, C; Maranhão, R. C.
  • Hosni, J. J; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo. BR
  • Vinagre, C. G; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo. BR
  • Mady, C; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo. BR
  • Maranhão, R. C; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo. BR
Braz. j. med. biol. res ; 40(3): 305-307, Mar. 2007.
Artículo en Inglés | LILACS | ID: lil-441770
ABSTRACT
Disorders of the lipid metabolism may play a role in the genesis of abdominal aorta aneurysm. The present study examined the intravascular catabolism of chylomicrons, the lipoproteins that carry the dietary lipids absorbed by the intestine in the circulation in patients with abdominal aorta aneurysm. Thirteen male patients (72 ± 5 years) with abdominal aorta aneurysm with normal plasma lipid profile and 13 healthy male control subjects (73 ± 5 years) participated in the study. The method of chylomicron-like emulsions was used to evaluate this metabolism. The emulsion labeled with 14C-cholesteryl oleate and ³H-triolein was injected intravenously in both groups. Blood samples were taken at regular intervals over 60 min to determine the decay curves. The fractional clearance rate (FCR) of the radioactive labels was calculated by compartmental analysis. The FCR of the emulsion with ³H-triolein was smaller in the aortic aneurysm patients than in controls (0.025 ± 0.017 vs 0.039 ± 0.019 min-1; P < 0.05), but the FCR of14C-cholesteryl oleate of both groups did not differ. In conclusion, as indicated by the triglyceride FCR, chylomicron lipolysis is diminished in male patients with aortic aneurysm, whereas the remnant removal which is traced by the cholesteryl oleate FCR is not altered. The results suggest that defects in the chylomicron metabolism may represent a risk factor for development of abdominal aortic aneurysm.
Asunto(s)

Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Trioleína / Ésteres del Colesterol / Quilomicrones / Aneurisma de la Aorta Abdominal / Lipólisis Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Anciano / Humanos / Masculino Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2007 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade de São Paulo/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Trioleína / Ésteres del Colesterol / Quilomicrones / Aneurisma de la Aorta Abdominal / Lipólisis Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Anciano / Humanos / Masculino Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2007 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade de São Paulo/BR