Clinicopathological Significance of BAT26Instability in 184 Patients with Colorectal Cancer
Appl. cancer res
;
25(1): 36-40, Jan.-Mar. 2005.
Artículo
en Inglés
| LILACS, Inca
| ID: lil-442292
ABSTRACT
Microsatellite instability (MSI) occurs in 90% ofcolorectal cancer (CRC) from HNPCC patients and 15%of sporadic CRC. Patients with CRC and MSI have adistinct phenotype. OBJECTIVE:
this study evaluates theisolated clinicopathological significance of BAT26instability by itself in patients with CRC.METHODS:
From 1995 to 2000, 184 patients submitted to CRC surgerywere selected at random. Medical records were studiedin order to determine clinical data and BAT26 analysiswas carried out.RESULTS:
BAT26 instability was foundin 22 (12%) of the 184 cases and was correlated to proximalcolon tumors (p<0.001); CRC from HNPCC patients(p=0.002); poor cell differentiation (p=0,025); andmucinous component (p=0,007). BAT26 instabilitytumors have shown a slight trend toward absence ofmetastases (p=0,082). The five-year cancer-specificsurvival was 65% and 85% for stable and instable BAT26,respectively, with no statistical significance.CONCLUSION:
BAT26 instability should be considereda useful screening method to select CRC patients forMSI.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neoplasias Colorrectales
/
Repeticiones de Microsatélite
Límite:
Humanos
Idioma:
Inglés
Revista:
Appl. cancer res
Asunto de la revista:
Neoplasmas
Año:
2005
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Hospital do Câncer A. C. Camargo/BR
/
Ludwig Institute for Cancer Research/BR
/
Universidade Federal de Minas Gerais/BR
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