Estatus inmunológico de las madres infectadas por T. cruzi / Immunological status of mothers infected with Trypanosoma cruzi
Rev. Soc. Bras. Med. Trop
;
38(supl.2): 101-104, 2005. graf
Artículo
en Español
| LILACS
| ID: lil-444165
ABSTRACT
The mechanisms of congenital transmission of Chagas disease remain largely unknown. To better understand the role of maternal immunology during pregnancy in congenital Chagas transmission, we studied the cytokine production and the parasitic load in three groups of mothers infected mothers who transmitted the disease to their babies (M+B+-), infected mothers who did not transmit the disease to their babies (M+B-) and not infected mothers as a control group (M-B-). M+B+ mothers produced less IFNgamma and more IL-10 than the M+B- mothers, and they are not able to produce IL-2. M+B+ mothers showed a higher parasitic load. These results, indicated that the congenital Chagas transmission is associated with an immunological imbalance and a high parasitic load in the M+B+ mothers.
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Índice:
LILACS (Américas)
Asunto principal:
Complicaciones Infecciosas del Embarazo
/
Trypanosoma cruzi
/
Citocinas
/
Enfermedad de Chagas
/
Transmisión Vertical de Enfermedad Infecciosa
Límite:
Animales
/
Femenino
/
Humanos
/
Embarazo
Idioma:
Español
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2005
Tipo del documento:
Artículo
/
Congreso y conferencia
País de afiliación:
Bélgica
/
Bolivia
Institución/País de afiliación:
Universidad Mayor de San Simón (UMSS)/BO
/
Université Livre de Bruxelles/BE
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