Implementación y evaluación de un sistema localmente sustentable de diagnostico prenatal que permite detectar casos de transmisión congénita de la enfermedad de Chagas en zonas endémicas del Paraguay / Implementation and evaluation of a locally sustainable system of prenatal diagnosis to detect cases of congenital Chagas disease in endemic areas of Paraguay
Rev. Soc. Bras. Med. Trop
;
38(supl.2): 49-54, 2005. tab
Artículo
en Español
| LILACS
| ID: lil-444177
ABSTRACT
A locally sustainable system of prenatal screening of Trypanosoma cruzi infection has been implemented in rural health care centers of endemic areas in Paraguay A total of 61.091 women from Paraguari and Cordillera Departments were serologically evaluated, where 7.802 (12,7%) resulted to be anti-T. cruzi IgG positive. A total of 1,865 infants born to seropositive mothers were examined by parasitological techniques, such as direct microscopic observation and polymerase chain reaction, and serologically by ELISA, ELISA-SAPA and IFI. 104 infected babies were detected and treated with benznidazole. The recovery of babies born to seropositive mothers performing a single examination at the age of 6 months was significantly higher, as compared with the recommended method involving two examinations, both at birth and after 6 months of age. Although at 6 months of age in 7% of the infants maternal IgG was still detected. PCR was the most sensitive technique for early detection of T. cruzi infection in babies, but we do not recommend it use for diagnosis in high endemic areas, considering that for the screening of 815 babies, 2000 reactions were needed. We propose a strategy to detect congenital transmission of Chagas disease, based on a large-scale study, where the shortcomings of the different serological and parasitological techniques are discussed.
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Índice:
LILACS (Américas)
Asunto principal:
Diagnóstico Prenatal
/
Atención Primaria de Salud
/
Tamizaje Neonatal
/
Enfermedad de Chagas
/
Enfermedades Endémicas
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Animales
/
Femenino
/
Humanos
/
Embarazo
País/Región como asunto:
America del Sur
/
Paraguay
Idioma:
Español
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
Medicina Tropical
Año:
2005
Tipo del documento:
Artículo
/
Congreso y conferencia
País de afiliación:
Paraguay
Institución/País de afiliación:
Ministerio de Salud Publica/PY
/
Universidad Nacional de Asunción/PY
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