Occurrence of extended-spectrum beta-lactamases in Enterobacteriaceae isolated from hospitalized patients in Curitiba, southern Brazil
Braz. j. infect. dis
;
10(6): 390-395, Dec. 2006. tab
Artículo
en Inglés
| LILACS
| ID: lil-446739
ABSTRACT
Production of extended-spectrum beta-lactamases (ESBL) by enterobacteria is an important resistance mechanism against antimicrobial beta-lactamics. We tested 498 bacterial strains isolated from two tertiary-care teaching hospitals for ESBL production, using screening breakpoints for aztreonam and third generation cephalosporins, according to CLSI recommendations. Among these isolates, 155 were positive for the ESBL screening test, and 121 (78 percent) were confirmed by the clavulanic acid combination disk method. We found a high frequency of ESBL (24 percent) among Enterobacteriaceae, with a frequency of 57.4 percent for Klebsiella pneumoniae, 21.4 percent for Klebsiella oxytoca, and 7.2 percent for E. coli. In other members of Enterobacteriaceae, non-Klebsiella and non-E. coli, the prevalence was 21.6 percent. Ceftriaxone and cefotaxime showed a higher sensitivity in the screening test (99.2 percent) when compared to ceftazidime, aztreonam and cefpodoxime. However, cefotaxime/cefotaxime plus clavulanic acid showed a higher sensitivity in the confirmatory test (96.7 percent).
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Beta-Lactamasas
/
Enterobacteriaceae
/
Antibacterianos
Tipo de estudio:
Factores de riesgo
Límite:
Humanos
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2006
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Catholic University of Paraná/BR
/
Federal University of Paraná/BR
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