Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo
Mem. Inst. Oswaldo Cruz
;
102(3): 417-420, June 2007. tab
Artículo
en Inglés
| LILACS
| ID: lil-452507
ABSTRACT
Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear. The present report presents the enhancement of the antimalarial efficacy of AQ by chlorpheniramine, an H1 receptor antagonist that reverses chloroquine (CQ) resistance in vitro and enhances its efficacy in vivo, in five children who failed CQ and/or AQ treatment, and who were subsequently retreated and cured with a combination of AQ plus CP, despite the fact that parasites infecting the children harboured mutant pfcrtT76 and pfmdr1Y86 alleles associated with AQ resistance. This suggests a potential clinical appliation of the reversal phenomenon.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Proteínas de Transporte de Membrana
/
Proteínas Protozoarias
/
Cloroquina
/
Clorfeniramina
/
Malaria Falciparum
/
Amodiaquina
/
Antagonistas de los Receptores Histamínicos H1
/
Antimaláricos
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2007
Tipo del documento:
Artículo
País de afiliación:
Nigeria
Institución/País de afiliación:
University of Ibadan/NG
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