Acute leukemia in early childhood
Braz. j. med. biol. res
;
40(6): 749-760, June 2007. tab
Artículo
en Inglés
| LILACS
| ID: lil-452685
ABSTRACT
Acute leukemia in early childhood is biologically and clinically distinct. The particular characteristics of this malignancy diagnosed during the first months of life have provided remarkable insights into the etiology of the disease. The pro-B, CD10 negative immunophenotype is typically found in infant acute leukemia, and the most common genetic alterations are the rearrangements of the MLL gene. In addition, the TEL/AML1 fusion gene is most frequently found in children older than 24 months. A molecular study on a Brazilian cohort (age range 0-23 months) has detected TEL/AML1+ve (N = 9), E2A/PBX1+ve (N = 4), PML/RARA+ve (N = 4), and AML1/ETO+ve (N = 2) cases. Undoubtedly, the great majority of genetic events occurring in these patients arise prenatally. The environmental exposure to damaging agents that give rise to genetic changes prenatally may be accurately determined in infants since the window of exposure is limited and known. Several studies have shown maternal exposures that may give rise to leukemogenic changes. The Brazilian Collaborative Study Group of Infant Acute Leukemia has found that mothers exposed to dipyrone, pesticides and hormones had an increased chance to give birth to babies with infant acute leukemia [OR = 1.48 (95 percentCI = 1.05-2.07), OR = 2.27 (95 percentCI = 1.56-3.31) and OR = 9.08 (95 percentCI = 2.95-27.96)], respectively. This review aims to summarize recent clues that have facilitated the elucidation of the biology of early childhood leukemias, with emphasis on infant acute leukemia in the Brazilian population.
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Índice:
LILACS (Américas)
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
/
Leucemia Mieloide
/
Regulación Neoplásica de la Expresión Génica
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Proteína de la Leucemia Mieloide-Linfoide
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudio:
Estudio de etiología
Límite:
Femenino
/
Humanos
/
Lactante
/
Recién Nacido
/
Embarazo
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2007
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
FIOCRUZ/BR
/
Instituto Nacional de Câncer/BR
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