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Comparison between PSA density, free PSA percentage and PSA density in the transition zone in the detection of prostate cancer in patients with serum PSA between 4 and 10 ng/ml
Gregorio, Emerson P; Grando, Joao P; Saqueti, Eufanio E; Almeida, Silvio H; Moreira, Horacio A; Rodrigues, Marco A.
  • Gregorio, Emerson P; State University of Londrina. Health Sciences Center. Department of Surgery. Section of Urology. Londrina. BR
  • Grando, Joao P; State University of Londrina. Health Sciences Center. Department of Surgery. Section of Urology. Londrina. BR
  • Saqueti, Eufanio E; State University of Londrina. Health Sciences Center. Department of Surgery. Section of Urology. Londrina. BR
  • Almeida, Silvio H; State University of Londrina. Health Sciences Center. Department of Surgery. Section of Urology. Londrina. BR
  • Moreira, Horacio A; State University of Londrina. Health Sciences Center. Department of Surgery. Section of Urology. Londrina. BR
  • Rodrigues, Marco A; State University of Londrina. Health Sciences Center. Department of Surgery. Section of Urology. Londrina. BR
Int. braz. j. urol ; 33(2): 151-160, Mar.-Apr. 2007. tab, graf
Artículo en Inglés | LILACS | ID: lil-455588
ABSTRACT

OBJECTIVE:

Compare the capacity of the PSA density (PSAD), Free PSA percentage ( percentFPSA) and PSA transition zone density (PSATZ) in improving the sensitivity and specificity of the PSA to detect prostate cancer (PCa) in men with a PSA between 4 and 10 ng/mL. MATERIALS AND

METHODS:

One hundred and forty five men with PSA between 4 and 10 ng/mL were prospectively studied. Blood collection for the total PSA and free PSA was performed as well as transrectal ultra-sound with prostate biopsy and measurement of the total prostate volume (TPV) and transition zone volume (TZV). Patients with initial negative biopsy were followed and the prostate biopsy was repeated in those that presented PSA increase. The capacity of the PSAD, percentFPSA and PSADTZ in improving the sensitivity and specificity pf the PSA test to the detection of the PCa was assessed by univariate and multivariate analyses and through the ROC curve.

RESULTS:

Of the 145 patients, 38 (26.2 percent) had PCa and in 107 (73.8 percent) a benign prostate disease was diagnosed. No difference among the PSAD, percentFPSA and PSADTZ was found. The multivariate analysis showed that the PSADTZ, percentFPSA, TZV and age were those more powerful and highly significant PCa predictors.

CONCLUSION:

The determination of percentFPSA and PSAD can allow a better discrimination between PCa and benign disease that the isolated use of PSA. The combination of PSADTZ, percentFPSA, TZV and age promote a high accuracy for PCa detection.
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Neoplasias de la Próstata / Adenocarcinoma / Antígeno Prostático Específico Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Límite: Anciano / Humanos / Masculino Idioma: Inglés Revista: Int. braz. j. urol Asunto de la revista: Urología Año: 2007 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: State University of Londrina/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Neoplasias de la Próstata / Adenocarcinoma / Antígeno Prostático Específico Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Límite: Anciano / Humanos / Masculino Idioma: Inglés Revista: Int. braz. j. urol Asunto de la revista: Urología Año: 2007 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: State University of Londrina/BR