Quantitative study of AgNOR in lingual mucosal cells of BALB/C mice submitted to the 4-NQO carcinogen: the effect of vitamin E / Quantificação das AgNOR em células da mucosa lingual de camundongos BALB/C submetidos ao 4-NQO: efeito da vitamina E

ABSTRACT

Animal models have shown to be important in understanding multifactorial diseases with complex mechanisms and multiple molecular events as in oral squamous cells carcinoma. 4-NQO exhibits a potent carcinogenic effect in various animal species, producing DNA mutations, altering base pairs, provoking deletions and chromosome aberrations. Micronutrients, among them, vitamin E may inactivate free radicals and reactive metabolites of oxygen, with are potent causes of DNA damage...