Correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengue / Association between glutathione peroxidase levels and clinical manifestations of dengue
Rev. méd. Chile
;
135(6): 743-750, jun. 2007. tab
Artículo
en Español
| LILACS
| ID: lil-459577
ABSTRACT
Background:
Glutathione peroxidase (GP) can be used as a marker of oxidative stress in infectious diseases.Aim:
To evaluate the association between the levels of glutathione peroxidase (GP) and the manifestations and complications of dengue. Patients andMethods:
Between April 2003 and December 2004, 161 patients with dengue were prospectively evaluated. In the first evaluation, within 48 and 96 hours of disease onset, a plasma sample was obtained to measure the GP levels. The association between GP levels, clinical manifestations and complications was evaluated during the follow up.Results:
Mean GP values were 1198 U/L (95 percent confidence interval 1089-1306). Values greater than 1200 U/L were associated with headache, arthralgias and increased heart rate. There was a negative association between GP levels and serum triglycerides. During follow up, patients with GP >1200 U/L had a higher frequency of spontaneous hemorrhages. In a logistic regression analysis arthralgias, fever and increased heart rate, were independently associated with levels >1200 U/L.Conclusions:
GP levels was associated to some of the manifestations of dengue. This finding suggests that the intensity of oxidative stress can influence the clinical presentation of dengue.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Estrés Oxidativo
/
Dengue
/
Glutatión Peroxidasa
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Anciano
/
Aged80
/
Niño
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Colombia
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2007
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Colombia
Institución/País de afiliación:
Universidad Industrial de Santander/CO
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