Inefficacy of the association N-methyl glucamine and topical miltefosine in the treatment of experimental cutaneous leishmaniasis by Leishmania (Leishmania) amazonensis
J. venom. anim. toxins incl. trop. dis
;
13(3): 598-606, 2007. graf, tab
Artículo
en Inglés
| LILACS, VETINDEX
| ID: lil-461646
ABSTRACT
Pentavalent antimonial (SbV) is the first treatment for cutaneous leishmaniasis (CL). Other drugs present similar side effects and higher cost. Oral miltefosine is effective to treat kala-azar. The aim of the present study was to compare the efficacy of glucamine (SbV) plus topical miltefosine with glucamine in the treatment of CL. Eighty isogenic C57BL/6 mice were inoculated with Leishmania (Leishmania) amazonensis and divided into two groups one group was treated with SbV associated with miltefosine, and the other group received SbV plus saline solution. Groups were evaluated according to the diameter of the inoculated foot pad, the culture, and the parasite count using the limiting dilution assay. There was not statistical difference. The efficacy of glucamine in CL treatment did not increase when associated with topical miltefosine.(AU)
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Preparaciones Farmacéuticas
/
Leishmaniasis Cutánea
/
Meglumina
Tipo de estudio:
Factores de riesgo
Idioma:
Inglés
Revista:
J. venom. anim. toxins incl. trop. dis
Año:
2007
Tipo del documento:
Artículo
Institución/País de afiliación:
University of Brasília/BR
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