Lack of association between matrix metalloproteinase-1 (MMP-1) promoter polymorphism and risk of renal cell carcinoma
Int. braz. j. urol
;
33(5): 622-629, Sept.-Oct. 2007. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-470212
ABSTRACT
OBJECTIVE:
Investigate the possible association of insertion/deletion (2G/G) polymorphism at nucleotide -1607 of the MMP-1 promoter with the development and progression of renal cancer MATERIALS ANDMETHODS:
In this study, we genotyped 217 individuals, 99 patients with renal cell carcinoma (RCC) and 118 controls without cancer. DNA specimens were extracted from epithelial buccal cells and paraffin-embedded tissue of RCC patients and from epithelial buccal cells and blood cells of healthy controlsRESULTS:
The difference in frequency of 2G/2G genotype between controls (22.9 percent) and RCC patients (28.6 percent) was not statistically significant (p = 0.461). We also did not find correlation between 2G/2G and histological type of RCC. The comparison of genotype distribution and frequency of 2G allele in different populations showed a strong variability of 2G allele frequency among the different ethnic groups. This fact may influence on the collaboration of this 2G allele in RCC or others diseasesCONCLUSION:
Our data suggest that the matrix metalloproteinase-1 (MMP-1) promoter polymorphism may not play a significant role in renal cell carcinoma patients in Brazil.
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Índice:
LILACS (Américas)
Asunto principal:
Carcinoma de Células Renales
/
Regiones Promotoras Genéticas
/
Metaloproteinasa 1 de la Matriz
/
Polimorfismo de Nucleótido Simple
/
Neoplasias Renales
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Int. braz. j. urol
Asunto de la revista:
Urología
Año:
2007
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of Sao Paulo/BR
/
Institute of Energetic and Nuclear Research/BR
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