Changes in histoanatomical distribution of types I, III and V collagen promote adaptative remodeling in posterior tibial tendon rupture
Clinics
; Clinics;63(1): 9-14, 2008. ilus
Article
en En
| LILACS
| ID: lil-474921
Biblioteca responsable:
BR1.1
ABSTRACT
INTRODUCTION:
Posterior tibial tendon dysfunction is a common cause of adult flat foot deformity, and its etiology is unknown.PURPOSE:
In this study, we characterized the morphologic pattern and distribution of types I, III and V collagen in posterior tibial tendon dysfunction.METHOD:
Tendon samples from patients with and without posterior tibial tendon dysfunction were stained by immunofluorescence using antibodies against types I, III and V collagen.RESULTS:
Control samples showed that type V deposited near the vessels only, while surgically obtained specimens displayed type V collagen surrounding other types of collagen fibers in thicker adventitial layers. Type III collagen levels were also increased in pathological specimens. On the other hand, amounts of collagen type I, which represents 95 percent of the total collagen amount in normal tendon, were decreased in pathological specimens.CONCLUSION:
Fibrillogenesis in posterior tibial tendon dysfunction is altered due to higher expression of types III and V collagen and a decreased amount of collagen type I, which renders the originating fibrils structurally less resistant to mechanical forces.Palabras clave
Texto completo:
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Índice:
LILACS
Asunto principal:
Colágeno Tipo I
/
Colágeno Tipo III
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Colágeno Tipo V
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Disfunción del Tendón Tibial Posterior
Tipo de estudio:
Observational_studies
Límite:
Adult
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Aged
/
Female
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Humans
Idioma:
En
Revista:
Clinics
/
Clinics (Online)
/
Clinics (Sao Paulo)
/
Clinics (Sao Paulo. Impresso)
Asunto de la revista:
MEDICINA
Año:
2008
Tipo del documento:
Article