Myeloproliferative syndrome of monosomy 7: a brief report
Genet. mol. biol
;
31(1): 36-38, 2008.
Artículo
en Inglés
| LILACS
| ID: lil-476147
ABSTRACT
We report the case of a five-month-old black male infant who had recurrent episodes of respiratory infections and also presented anemia and enlargements of the spleen, liver and lymphnodes. Hematological analysis revealed morphological abnormalities with megaloblastic dyserythropoiesis, while fetal hemoglobin assaying showed normal levels. Conventional and molecular cytogenetic analysis revealed monosomy of chromosome 7. Despite all therapeutic efforts during allogenic bone marrow transplantation, the child died due to generalized infection. The clinical and genetic distinctions between monosomy 7 syndrome and myelodysplastic disorders in childhood are discussed.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Síndromes Mielodisplásicos
/
Monosomía
/
Trastornos Mieloproliferativos
Límite:
Humanos
/
Lactante
/
Masculino
Idioma:
Inglés
Revista:
Genet. mol. biol
Asunto de la revista:
Genética
Año:
2008
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Instituto Nacional do Câncer/BR
/
Universidade Federal de Pernambuco/BR
/
Universidade de Pernambuco/BR
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