Major histocompatibility complex class II polymorphisms and risk of cervical cancer in Puerto Rican women
P. R. health sci. j
;
26(2): 97-101, Jun. 2007.
Artículo
en Inglés
| LILACS
| ID: lil-476404
ABSTRACT
Association between HLA antigens and cervical squamous cell carcinoma has been described in several populations. To verify whether HLA-DRB1 and DQB1 diversity is related to cervical cancer in Puerto Rican women, 40 cases and 50 controls were HLA typed. DRB1*16 (POR=2.89) and DRB1*11 (POR=1.74) were positively associated with cervical cancer. A negative association was found with DRB1*01 (POR=0.52), DRB1*04 (POR=0.60), DRB1*14 (POR=0.33), DRB1*15 (POR=0.65), DQB1*04 (POR=0.33), DQB1*05 (POR=0.64) and DQB1*06 (POR=0.65). We suggest that HLA Class H polymorphisms are involved in genetic susceptibility to cervical cancer in Puerto Rican women. These results should be confirmed in studies with larger sample size to preclude the possibility of false positive observations.
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Índice:
LILACS (Américas)
Asunto principal:
Antígenos de Histocompatibilidad Clase II
/
Neoplasias del Cuello Uterino
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Adulto
/
Anciano
/
Aged80
/
Femenino
/
Humanos
País/Región como asunto:
Caribe
/
Puerto Rico
Idioma:
Inglés
Revista:
P. R. health sci. j
Asunto de la revista:
Medicina
Año:
2007
Tipo del documento:
Artículo
País de afiliación:
Puerto Rico
Institución/País de afiliación:
University of Puerto Rico/PR
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