Patterns of co-association of C-reactive protein and nitric oxide in malaria in endemic areas of Iran
Mem. Inst. Oswaldo Cruz
;
103(1): 39-44, Feb. 2008. graf, tab
Artículo
en Inglés
| LILACS
| ID: lil-478875
ABSTRACT
In addition to numerous immune factors, C-reactive protein (CRP) and nitric oxide (NO) are believed to be molecules of malaria immunopathology. The objective of this study was to detect CRP and NO inductions by agglutination latex test and Griess microassay respectively in both control and malaria groups from endemic areas of Iran, including Southeastern (SE) (Sistan & Balouchestan, Hormozgan, Kerman) and Northwestern (NW) provinces (Ardabil). The results indicated that CRP and NO are produced in all malaria endemic areas of Iran. In addition, more CRP and NO positive cases were observed amongst malaria patients in comparison with those in control group. A variable co-association of CRP/NO production were detected between control and malaria groups, which depended upon the malaria endemic areas and the type of plasmodia infection. The percentage of CRP/NO positive cases was observed to be lower in NW compare to SE region, which may be due to the different type of plasmodium in the NW (Plasmodium vivax) with SE area (P. vivax, Plasmodium falciparum, mixed infection). The fluctuations in CRP/NO induction may be consistent with genetic background of patients. Although, CRP/NO may play important role in malaria, their actual function and interaction in clinical forms of disease remains unclear.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Proteína C-Reactiva
/
Malaria Vivax
/
Malaria Falciparum
/
Óxido Nítrico
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Animales
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2008
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Irán
Institución/País de afiliación:
Health Center of West Azerbaijan Province/IR
/
Pasteur Institute of Iran/IR
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