In vivo qualitative analysis of the biocompatibility of different cyanoacrylate-based adhesives
Braz. oral res
;
22(1): 43-47, Jan.-Mar. 2008. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-480582
ABSTRACT
Cyanocrylates have been widely used in the medical and dental fields for several years. In Dentistry, cyanoacrylates have been used for suturing, pulp capping, as retrofilling material in endodontic surgeries, and as cervical plug for pulpless teeth bleaching. The biocompatibility of these adhesives has been the topic of many researches and subcutaneous implantation is an effective methodology for these studies. The present study evaluated the biocompatibility of three different cyanoacrylate-based adhesives. Thirty-six Wistar rats were used, divided into four groups of 9 animals each A (control) - distilled water, B - cyanoacrylate ester (Super Bonder), C - n-butyl-cyanoacrylate (Histoacryl) and D - alpha-cyanoacrylate (Three Bond). The materials were dispensed in sponges of polyvinyl chloride, the animals were incised and the sponges were inserted in the subcutaneous tissue and sutured. Each group was sub-divided according to the time of sacrifice of the animals 7, 21 and 45 days. Subjective analysis of the histologic material showed that all groups presented some degree of irritability, but the inflammatory reaction decreased with the experimental time in all groups. Group D showed an inflammatory reaction which was closer to that of the control group and was considered to have good biocompatibility. Groups B and C were similar and presented more aggressive inflammatory reactions when compared to the control group. Based on the results, it was concluded that alpha-cyanoacrylate (Three Bond) was the most biocompatible adhesive because it caused the lowest levels of inflammation.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Materiales de Obturación del Conducto Radicular
/
Materiales Biocompatibles
/
Adhesivos
/
Retención de Dentadura
/
Cianoacrilatos
/
Tejido Subcutáneo
Tipo de estudio:
Estudio de etiología
/
Investigación cualitativa
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. oral res
Asunto de la revista:
Odontología
Año:
2008
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of Alfenas/BR
/
University of São Paulo/BR
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