Alta prevalencia de trastorno específico de lenguaje en isla Robinson Crusoe y probable efecto fundador / High prevalence of specific language impairment in Robinson Crusoe Island. A possible founder effect
Rev. méd. Chile
;
136(2): 186-192, feb. 2008. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-483238
ABSTRACT
Specific language impairment (SLI) occurs in 2 percent to 8 percent of preschool children. Major and candidate genes are probably involved. Genetic drift is a cause for the presence of high frequencies of deleterious alíeles of a specific disease and the founder effect is one of its forms. Robinson Crusoe Island has 633 inhabitants and its actual population began with 8 families that repopulated the island at the end ofXIXth century. Aim To assess the frequency of specific language impairment among children living in Robinson Crusoe Island. Material and methods:
All 66 children aged between 3 and 9 years living in the island, were studied. Parents were interviewed and in children, non verbal intelligence, audiometric parameters, comprehension and expression of oral language were assessed. Extended genealogies were also performed.Results:
Forty children had at least one parent that was descending of founder families. Among these, 35 percent had SLI. Eighth five percent of SLI affected children came from the same colonizer family.Conclusions:
The prevalence of SLI in Robinson Crusoe Island is higher than that reponed in mainland Chile and abroad. This high prevalence, associated to a high frequency of consanguinity, supports the influence of genetic mechanisms in SLI transmission, based on a founder effect.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Efecto Fundador
/
Consanguinidad
/
Trastornos del Desarrollo del Lenguaje
Tipo de estudio:
Estudio diagnóstico
/
Estudio de prevalencia
/
Factores de riesgo
/
Estudio de tamizaje
Límite:
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Chile
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2008
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de Chile/CL
Similares
MEDLINE
...
LILACS
LIS