Anatomopathological study in BALB/c mice brains experimentally infected with Toxoplasma gondii
Braz. j. infect. dis
;
12(1): 52-56, Feb. 2008. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-484419
ABSTRACT
Toxoplasmosis is one of the most important diseases of the nervous central system, leading to severe symptoms and, many times, irreversible sequelae. This work demonstrated the main anatomopathological lesions caused by Toxoplasma gondii in brains from experimentally infected BALB/c mice. We analyzed 51 cases of mice that developed toxoplasmosis after experimental infection by intraperitoneal inoculation of blood, amniotic liquid and cerebrospinal fluid from fetuses, newly born children and pregnant women with clinical and laboratory signals of toxoplasmosis. In all experiments where we detected the parasite in mice we also detected pathological lesions in the animal brains with great polymorphism between experiments. Edema was the most found lesion in all cases. Besides, it was possible to demonstrate the inflammatory process in 82.4 percent of cases and necrosis in 64.7 percent of cases, in agreement with the literature that describes severe neurological damage in its hosts.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Encéfalo
/
Toxoplasmosis Animal
/
Infecciones Protozoarias del Sistema Nervioso Central
Límite:
Animales
/
Femenino
/
Humanos
/
Embarazo
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2008
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of Goias/BR
/
UFG/BR
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