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Histopathological findings in extended prostate biopsy with PSA ≤ 4 ng/mL
Leite, Katia R; Srougi, Miguel; Dall'Oglio, Marcos F; Sanudo, Adriana; Camara-Lopes, Luiz H.
Afiliación
  • Leite, Katia R; USP. Division of Urology. Laboratory of Medical Investigation. São Paulo. BR
  • Srougi, Miguel; USP. Division of Urology. Laboratory of Medical Investigation. São Paulo. BR
  • Dall'Oglio, Marcos F; USP. Division of Urology. Laboratory of Medical Investigation. São Paulo. BR
  • Sanudo, Adriana; USP. Division of Urology. Laboratory of Medical Investigation. São Paulo. BR
  • Camara-Lopes, Luiz H; USP. Division of Urology. Laboratory of Medical Investigation. São Paulo. BR
Int. braz. j. urol ; 34(3): 283-292, May-June 2008. tab
Article en En | LILACS | ID: lil-489587
Biblioteca responsable: BR1.1
ABSTRACT

OBJECTIVE:

Cancer detection has been reported in up to 27 percent of patients when lowering the PSA cutoff to 2.5 ng/mL. Although this practice could increase the number of biopsies performed, it also could lead to more frequent detection of significant prostate cancers at an organ-confined stage and/or a less aggressive state. This study describes the incidence of malignancy and tumor characteristics in extended prostate biopsies with PSA ≤ 4 ng/mL. MATERIALS AND

METHODS:

Prostate biopsies from 1081 patients where examined, 275 (25.4 percent) patients had PSA level ≤ 4 ng/mL.

RESULTS:

Cancer was diagnosed in 32.0 percent and 35.7 percent of patients with PSA ≤ 4 ng/mL and > 4 ng/mL, respectively (p = 0.906). The median Gleason score was 7 independent of PSA > or ≤ 4 ng/mL (p = 0.078). The median number of cores positive for tumor was 4 and 3, respectively, for PSA > 4 ng/mL and PSA ≤ 4 ng/mL (p = 0.627). There was a difference in the total percent of tumors involving all cores, 11 percent and 7 percent for PSA > or ≤ 4 ng/mL (p = 0.042). Fifty-six patients underwent radical prostatectomy, 12 had PSA ¡Ü 4 ng/mL. In both groups, a diagnosis of cancer was accurate with no differences in Gleason score, tumor volume or staging for both groups.

CONCLUSION:

When PSA is below 4 ng/mL, cancer is detected in a proportion equal to the proportion diagnosed with a PSA > 4 ng/mL, and tumor characteristics are similar between the two groups. Only clinically significant tumors were diagnosed following radical prostatectomy.
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Texto completo: 1 Índice: LILACS Asunto principal: Próstata / Prostatectomía / Neoplasias de la Próstata / Adenocarcinoma / Antígeno Prostático Específico Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Adult / Aged / Aged80 / Humans / Male Idioma: En Revista: Int. braz. j. urol Asunto de la revista: UROLOGIA Año: 2008 Tipo del documento: Article
Texto completo: 1 Índice: LILACS Asunto principal: Próstata / Prostatectomía / Neoplasias de la Próstata / Adenocarcinoma / Antígeno Prostático Específico Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Adult / Aged / Aged80 / Humans / Male Idioma: En Revista: Int. braz. j. urol Asunto de la revista: UROLOGIA Año: 2008 Tipo del documento: Article