Effects of prenatal stress on male offspring sexual maturity
Biocell
;
31(1): 67-74, abr. 2007. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-491531
ABSTRACT
Prenatal stimulations have been shown to have long-term effects on at reproductive activity. We evaluated the influence of the prenatal stress on the hypothalamic-pituitary-gonad (HPG) axis in male offsprings from mothers with high number of offsprings per litter (HNL) and low number of offsprings per litter (LNL) after hypothesizing that the number of offsprings per litter may modify the effect of the prenatal stress on the HPG of adult offsprings. Pregnant Wistar rats were used for this study. Immobilization (IMO) stress was used, 30 min, 3 times per week, from the 5th to 21st day of pregnancy. The weight of adrenal and gonads, and the corticosterone (COR), testosterone (TES) and luteinizing hormone (LH) plasmatic levels were analyzed in the male offspring at 30, 45 and 70 days of age. The offspring males coming from LNL showed a decrease in testicle weight and TES levels, without changes in the plasmatic LH levels. However, the offspring of HNL showed a decrease of LH levels. It is possible to conclude that in LNL prenatal stress would produce alterations to gonadal level, while in HNL the effect of stress would be evident at pituitary level.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Hipófisis
/
Maduración Sexual
/
Estrés Fisiológico
/
Testículo
/
Corticosterona
/
Hormona Luteinizante
/
Hipotálamo
Tipo de estudio:
Estudio de etiología
Límite:
Animales
/
Embarazo
Idioma:
Inglés
Revista:
Biocell
Asunto de la revista:
Clulas
Año:
2007
Tipo del documento:
Artículo
País de afiliación:
Argentina
Institución/País de afiliación:
Universidad Nacional de Río Cuarto/AR
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