Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
Mem. Inst. Oswaldo Cruz
;
103(6): 549-553, Sept. 2008. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-495743
ABSTRACT
Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas disease. As recent studies have de-monstrated cardiotoxic effects of Nfx, we attempted to determine whether Bz behaves similarly. Bz reached the heart tissue of male rats after intragastric administration. No cytosolic Bz nitroreductases were detected, although microsomal NADPH-dependent Bz nitroreductase activity was observed, and appeared to be mediated by P450 reductase. No ultrastructurally observable deleterious effects of Bz were detected, in contrast to the overt cardiac effects previously reported for Nfx. In conclusion, when these drugs are used in chagasic patients, Bz may pose a lesser risk to heart function than Nfx when any cardiopathy is present.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Tripanocidas
/
Corazón
/
Miocardio
/
Nifurtimox
/
Nitroimidazoles
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2008
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Argentina
Institución/País de afiliación:
Centro de Investigaciones Toxicológicas/AR
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