Hipopituitarismo congénito: experiencia en 23 casos / Congenital hypopituitarism: report of 23 cases
Rev. méd. Chile
;
136(8): 996-1006, ago. 2008. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-495798
ABSTRACT
Background:
Congenital hypopituitarism is an uncommon cause of hypophyseal insufficiency It is less common than growth hormone deficiency which has an incidence of 14.000 to 18.000 Uve newborns. Early diagnosis ofthis condition is important to prevent impairment of cognitive function, poor growth and alterations in metabolic profile in these patients.Aim:
To report 23 patients diagnosed with congenital hypopituitarism. Material andmethods:
Retrospective review of clinical records of 23 patients (12 males) with congenital hypopituitarism, diagnosed during a 21 years period. In a group of 16 patients a molecular study was performed searching for mutations in HESX1, PROP-1 or POUF-1.Results:
Short stature was the most frequent sign at the first evaluation, followed by neonatal hypoglycemia and presence of nistagmus, strabismus, atrophic optic nerve or malformations in the middle Une showed in CNS imaging, suggesting septo-optic-dysplasia. All male patients diagnosed during neonatal period, exhibited micropenis. CNS images showed isolated hypophyseal hypoplasia or associated to an ectopic neurohypophysis in most patients. No patient in the subgroup subjected to molecular analysis had any of the mutations in the searched genes.Conclusions:
The diagnosis of hypopituitarism must be based on clinical grounds, speciaUy when hypoglycemia, prolonged jaundice, micropenis or midline alterations are found in the neonatal period.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Hipopituitarismo
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
/
Estudio de tamizaje
Límite:
Adolescente
/
Niño
/
Child, preschool
/
Femenino
/
Humanos
/
Lactante
/
Masculino
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2008
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Sociedad Chilena de Endocrinología y Diabetes/CL
/
Universidad de Chile/CL
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