Intracoronary radionuclide therapy with liquid 188Re-filled balloons; radiopharmaceutical and dosimetric studies
Rev. med. nucl. Alasbimn j
;
10(41)jul. 2008. ilus, tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-495997
ABSTRACT
Percutaneous transluminal coronary angioplasty associated with radioactive liquid-filled balloons has demostrated to be useful to inhibit the growth of neointimal tissue. The present study pursued optimizing the relation risk/benefit during a procedure of brachytherapy with 188Re associated to angioplasty. Since the possibility of balloon rupture exists, to increase the security during the treatment different agents such as 188Re-DTPA, 188Re-Citrate and 188Re-EC vs 188ReO4 were evaluated. Dosimetric studies using Mirdose 3, after iv injection to Wistar rats, evaluation of a number of safety requirements in order to estimate radiation dose delivered to operating personnel and absorbed doses estimated by Monte Carlo method (PENELOPE). It is a safe procedure, both for the patient and the working staff; in case of ballon rupture the use of the above mentioned radiopharmaceuticals increases its security. 188Re beta emitor achieves a local dosis, diminishing the dose in healthy tissue.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Radioisótopos
/
Renio
/
Enfermedad Coronaria
Tipo de estudio:
Evaluación Económica en Salud
Límite:
Animales
Idioma:
Inglés
Revista:
Rev. med. nucl. Alasbimn j
Asunto de la revista:
Medicina Nuclear
Año:
2008
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Argentina
/
Estados Unidos
/
Uruguay
Institución/País de afiliación:
Food and Drug Administration/US
/
Universidad Nacional de Córdoba/AR
/
Universidad de la República/UY
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