Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis?
J. venom. anim. toxins incl. trop. dis
;
14(4): 738-749, 2008. ilus, tab
Artículo
en Inglés
| LILACS, VETINDEX
| ID: lil-500141
ABSTRACT
The unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation and measurement of heavy metals (copper) in the kidneys and in the liver were carried out. Blood counts revealed anemia and serological tests showed high levels of blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphokinase, total bilirubin and indirect bilirubin; which indicates liver, kidney and skeletal muscle damages. At necropsy, the animal presented hepatopathy and nephropathy. Histological examination revealed renal and hepatic features that may imply copper intoxication. Copper levels were 237.8 µg/g in the liver and 51.2 µg/g in the kidneys. Although the amount of metal found in both organs was below the level that can cause death, according to the literature, anatomopathological signs were suggestive of copper intoxication. Therefore, the hypothesis of metal toxicosis during the hyperimmunization process became more consistent than the crotalic envenomation one.(AU)
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Nitrógeno de la Urea Sanguínea
/
Pruebas Serológicas
/
Ovinos
/
Crotalus cascavella
/
Creatina Quinasa
/
Muerte
Tipo de estudio:
Estudio diagnóstico
Límite:
Animales
Idioma:
Inglés
Revista:
J. venom. anim. toxins incl. trop. dis
Año:
2008
Tipo del documento:
Artículo
Institución/País de afiliación:
Nuclear Energy Research Institute/BR
/
São Paulo State University/BR
Similares
MEDLINE
...
LILACS
LIS