MTHFR, prothrombin and Factor V gene variants in Turkish patients with coronary artery stenosis
Genet. mol. biol
;
31(4): 836-838, Sept.-Dec. 2008. tab
Artículo
en Inglés
| LILACS
| ID: lil-501465
ABSTRACT
Many epidemiological studies have reported an association between hemostatic factors and risk of both coronary and peripheral artery diseases. Using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated the association between coronary artery disease and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) genes. We screened these gene variants in 174 subjects who had undergone coronary angiography - 115 patients with patent coronary artery disease (grade 3 vessel disease, i.e., significant coronary stenosis), and 59 healthy controls with grade 0 vessel disease. The analysis of our data did not show any statistically significant association between coronary artery disease (CAD) and the investigated polymorphisms.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Factor V
/
Protrombina
/
Estenosis Coronaria
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Genet. mol. biol
Asunto de la revista:
Genética
Año:
2008
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Maltepe University/TR
/
Marmara University/TR
/
Namik Kemal University/TR
/
Safak Hospital/TR
Similares
MEDLINE
...
LILACS
LIS