Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
Mem. Inst. Oswaldo Cruz
;
103(8): 773-777, Dec. 2008. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-502296
ABSTRACT
A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives.
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Asunto principal:
Terpenos
/
Leishmania braziliensis
/
Ciclohexenos
/
Amino Alcoholes
/
Antiprotozoarios
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2008
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
Fiocruz/BR
/
Universidade Federal do Rio Grande do Sul/BR
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