Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil
Braz. j. infect. dis
;
12(5): 353-354, Oct. 2008.
Artículo
en Inglés
| LILACS
| ID: lil-505344
ABSTRACT
We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline was used. We measured the quinine in the plasma samples on days 0 and 3by high performance liquid chromatography. The mean concentration of quinine was 6.04 ±2.21 µg/mL in male patients and 5.98 ±1.95 µg/mL in female patients. No significant differences in quinine concentration were observed between these two groups. All samples collected before starting treatment were negative for quinine. This information could help in the development of strategies for the rational use of antimalarial drugs in Brazil.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Quinina
/
Malaria Falciparum
/
Antimaláricos
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Animales
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2008
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of Pará/BR
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