Molecular investigation of a fungemia outbreak due to Candida parapsilosis in an intensive care unit
Braz. j. infect. dis
;
12(5): 395-399, Oct. 2008. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-505353
ABSTRACT
We investigated a nosocomial cluster of four Candida parapsilosis fungemia episodes that occurred in a neurological intensive care unit over a two-week period. The four infected patients had received parenteral nutrition through central lines, and all four had catheter-related candidemia. All of the isolates were susceptible to all of the antifungals tested, including amphotericin B, fluconazole, voriconazole, and caspofungin. They had strictly related fingerprints, based on randomly amplified polymorphic DNA analysis. Additional DNA sequencing data revealed that they were same strain. Although no isolate of Candida parapsilosis was recovered from other clinical, surveillance, or environmental samples, nosocomial spread of this yeast ceased, following the reinforcement of infection-control measures. Candida parapsilosis may require an intravascular foreign body to cause fungemia, but this outbreak shows that it can be transmitted nosocomially and can cause epidemics.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Candida
/
Candidiasis
/
Infección Hospitalaria
/
Brotes de Enfermedades
/
Fungemia
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Factores de riesgo
Límite:
Anciano
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2008
Tipo del documento:
Artículo
País de afiliación:
Japón
/
Turquía
Institución/País de afiliación:
Gazi University/TR
/
Meiji Pharmaceutical University/JP
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