Nuclear calcium signaling: a cell within a cell
Braz. j. med. biol. res
; 42(1): 17-20, Jan. 2009. ilus
Article
en En
| LILACS
| ID: lil-505417
Biblioteca responsable:
BR1.1
ABSTRACT
Calcium (Ca2+) is a versatile second messenger that regulates a wide range of cellular functions. Although it is not established how a single second messenger coordinates diverse effects within a cell, there is increasing evidence that the spatial patterns of Ca2+ signals may determine their specificity. Ca2+ signaling patterns can vary in different regions of the cell and Ca2+ signals in nuclear and cytoplasmic compartments have been reported to occur independently. No general paradigm has been established yet to explain whether, how, or when Ca2+ signals are initiated within the nucleus or their function. Here we highlight that receptor tyrosine kinases rapidly translocate to the nucleus. Ca2+ signals that are induced by growth factors result from phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol 1,4,5-trisphosphate formation within the nucleus rather than within the cytoplasm. This novel signaling mechanism may be responsible for growth factor effects on cell proliferation.
Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Núcleo Celular
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Proteínas Tirosina Quinasas Receptoras
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Señalización del Calcio
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Proliferación Celular
Límite:
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2009
Tipo del documento:
Article
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Congress and conference
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Project document