Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation
Braz. j. med. biol. res
; 42(2): 148-154, Feb. 2009. ilus
Article
en En
| LILACS
| ID: lil-506882
Biblioteca responsable:
BR1.1
ABSTRACT
In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the "reconsolidation hypothesis".
Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Reacción de Prevención
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FN-kappa B
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NG-Nitroarginina Metil Éster
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Memoria
Límite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2009
Tipo del documento:
Article
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Congress and conference