Molecular genotyping and epidemiology of Mycobacterium tuberculosis isolates obtained from inmates of correctional institutions of Campinas, Southeast Brazil
Braz. j. infect. dis
;
12(6): 487-493, Dec. 2008. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-507448
ABSTRACT
The objective of this study was to investigate the possible transmission of tuberculosis among 39 inmates with positive Mycobacterium tuberculosis smears in four correctional institutions located in Campinas City, SP, Brazil over a 19-month period. Fifty-one M. tuberculosis isolates from these inmates were characterized according to the number of IS6110 insertion elements present in their genomic DNA. The number of insertion elements in M. tuberculosis isolates varied from two to twelve. The dendrogram of similarity resulted in the grouping the isolates in six main clusters. These results, associated to epidemiological data, suggested the transmission of tuberculosis among inmates of the same and different institutions inmates. Univariate analysis of epidemiological data (total delay for beginning of treatment, previous treatment, and HIV status) and clustering occurrence showed that only "previous treatment" (OR = 7.65, p = 0.032) was associated with the possible transmission of tuberculosis in the studied prisons.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Prisiones
/
Tuberculosis Pulmonar
/
ADN Bacteriano
/
Mycobacterium tuberculosis
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
/
Estudio de tamizaje
Límite:
Adulto
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2008
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Adolfo Lutz Institute of Campinas/BR
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