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Comparison of intraperitoneal honey and sodium hyaluronate-carboxymethylcellulose (SeprafilmTM) for the prevention of postoperative intra-abdominal adhesions
Emre, Arif; Akin, Murat; Isikgonul, Ipek; Yuksel, Osman; Anadol, Ahmet Ziya; Cifter, Cagatay.
  • Emre, Arif; Gazi University Medical School. Department of General Surgery. Ankara. TR
  • Akin, Murat; Gazi University Medical School. Department of General Surgery. Ankara. TR
  • Isikgonul, Ipek; Gazi University Medical School. Department of Pathology. Ankara. TR
  • Yuksel, Osman; Gazi University Medical School. Department of General Surgery. Ankara. TR
  • Anadol, Ahmet Ziya; Gazi University Medical School. Department of General Surgery. Ankara. TR
  • Cifter, Cagatay; Gazi University Medical School. Department of General Surgery. Ankara. TR
Clinics ; 64(4): 363-368, 2009. ilus, tab
Artículo en Inglés | LILACS | ID: lil-511940
ABSTRACT

BACKGROUND:

Abdominal surgery can lead to postoperative intra-abdominal adhesions (PIAAs) with significant morbidity and mortality. This study compares the use of honey with a standard bioresorbable membrane (Seprafilm tm) to prevent the formation of PIAAs in rats.

METHODS:

Thirty rats underwent laparotomy, and PIAAs were induced by scraping the cecum. The animals were divided into three groups, each containing ten rats. Group 1 (control) represented the cecal abrasion group, with no intraperitoneal administration of any substance. Group 2 (honey group) underwent cecal abrasion and intraperitoneal administration of honey. Group 3 (Seprafilm tm group) underwent cecal abrasion and intraperitoneal Seprafilm tm application.

RESULTS:

Group 1 exhibited higher adhesion scores for adhesions between the abdominal wall and the organs. Groups 2 and 3 had decreased adhesive attachments to the intra-abdominal structures. Compared to group 1, the incidence of adhesion formation was lower in both group 2 (p=0.001) and group 3 (p=0.001). The incidence of fibrosis was also lower in group 2 (p=0.016) and group 3 (p=0.063) compared to group 1. There was no significant difference between the histopathological fibrosis scores for the rats in group 2 and those in group 3 (p= 0.688).

CONCLUSION:

This study suggests that both honey and Seprafilm tm decrease the incidence of PIAAs in the rat cecal abrasion model. Although the mechanism of action is not clear, intraperitoneal administration of honey reduced PIAAs. The outcome of this study demonstrates that honey is as effective as Seprafilm tm in preventing PIAAs.
Asunto(s)

Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Materiales Biocompatibles / Adherencias Tisulares / Apiterapia / Ácido Hialurónico Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Clinics Asunto de la revista: Medicina Año: 2009 Tipo del documento: Artículo País de afiliación: Turquía Institución/País de afiliación: Gazi University Medical School/TR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Materiales Biocompatibles / Adherencias Tisulares / Apiterapia / Ácido Hialurónico Tipo de estudio: Estudio pronóstico Límite: Animales Idioma: Inglés Revista: Clinics Asunto de la revista: Medicina Año: 2009 Tipo del documento: Artículo País de afiliación: Turquía Institución/País de afiliación: Gazi University Medical School/TR