Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population
Genet. mol. biol
;
32(2): 264-267, 2009. tab
Artículo
en Inglés
| LILACS
| ID: lil-513967
ABSTRACT
Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95 percent of cases with the Factor V Leiden allele (FVL or R506Q). Several recent studies report a further increased risk of thrombosis by an association between the AB alleles of the ABO blood group and Factor V Leiden. The present study investigated this association with deep vein thrombosis (DVT) in individuals treated at the Hemocentro de Pernambuco in northeastern Brazil. A case-control comparison showed a significant risk of thrombosis in the presence of Factor V Leiden (OR = 10.1), which was approximately doubled when the AB alleles of the ABO blood group were present as well (OR = 22.3). These results confirm that the increased risk of deep vein thrombosis in the combined presence of AB alleles and Factor V Leiden is also applicable to the Brazilian population suggesting that ABO blood group typing should be routinely added to FVL in studies involving thrombosis.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Genet. mol. biol
Asunto de la revista:
Genética
Año:
2009
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Fundação Centro de Hematologia e Hemoterapia de Pernambuco/BR
/
Fundação Centro de Hemoterapia e Hematologia do Pará/BR
Similares
MEDLINE
...
LILACS
LIS