Urinary fluoride output in children following the use of a dual-fluoride varnish formulation
J. appl. oral sci
;
17(3): 179-183, May-June 2009. graf, tab
Artículo
en Inglés
| LILACS
| ID: lil-514029
ABSTRACT
OBJECTIVE:
This study evaluated the bioavailability of fluoride after topical application of a dual-fluoride varnish commercially available in Brazil, when compared to DuraphatTM. MATERIAL ANDMETHODS:
The urinary fluoride output was evaluated in seven 5-year-old children after application of the fluoride varnishes, in two different phases. In the first phase (I), children received topical application of the fluoride varnish Duofluorid XII (2.92 percent fluorine, calcium fluoride + 2.71 percent fluorine, sodium fluoride, FGM TM). After 1-month interval (phase II), the same amount (0.2 mL) of the fluoride varnish Duraphat (2.26 percent fluorine, sodium fluoride, ColgateTM) was applied. Before each application all the volunteers brushed their teeth with placebo dentifrice for 7 days. Urinary collections were carried out 24 h prior up to 48 h after the applications. Fluoride intake from the diet was also estimated. Fluoride concentration in diet samples and urine was analyzed with the fluoride ion-specific electrode and a miniature calomel reference electrode coupled to a potentiometer. Data were tested by ANOVA and Tukey's post hoc test (p<0.05).RESULTS:
There were significant differences in the urinary fluoride output between phases I and II. The use of Duofluorid XII did not significantly increase the urinary fluoride output, when compared to baseline levels. The application of Duraphat caused a transitory increase in the urinary fluoride output, returning to baseline levels 48 h after its use.CONCLUSIONS:
The tested varnish formulation, which has been shown to be effective in in vitro studies, also can be considered safe.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Fluoruro de Sodio
/
Cariostáticos
/
Fluoruros Tópicos
/
Fluoruros
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Child, preschool
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
J. appl. oral sci
Asunto de la revista:
Odontología
Año:
2009
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Aparício Carvalho Integrated Faculty/BR
/
São Paulo State University/BR
/
University of São Paulo/BR
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