Oral clefts, consanguinity, parental tobacco and alcohol use: a case-control study in Rio de Janeiro, Brazil
Braz. oral res
;
23(1): 31-37, 2009. tab
Artículo
en Inglés
| LILACS
| ID: lil-514639
ABSTRACT
This hospital-based, case-control study investigated the possible associations between family history of malformations, parental consanguinity,smoking and alcohol drinking and nonsyndromic orofacial cleft (OC, subdivided in 2 main groups CL/P - cleft lip with or without cleft palate and CP - cleft palate alone). 274 cases were matched (age, sex and place of residence) to 548 controls. Odds ratios (OR) and 95% confi dence intervals (95% CI) adjusted for maternal age, schooling and smoking / alcohol use were calculated by conditional logistic regression. The results demonstrated that the history of oral clefts either in thefathers (CL/P OR = 16.00, 5.64- 9.23; CP OR = 6.64, 1.48-33.75) or in the mothers family (CL/P OR = 5.00, 2.31-10.99, CP OR = 12.44, 1.33-294.87) was strongly associated with both types of clefts, but parental consanguinity was associated only with CL/P (OR = 3.8, 1.27-12.18). Prevalence of maternal smoking during the fi rst trimester of pregnancy was higher among cases but the OR (1.13, 0.81-1.57) was not statistically signifi cant. Maternal passive smoking (nonsmoking mothers) during pregnancy was associated with CL/P (1.39, 1.01-1.98) but not with CP.Maternal alcohol use during the 1st trimester increased odds for CL/P (OR = 2.08, 1.27-3.41) and CP (OR = 2.89, 1.25-8.30), and odds for OC tended to increase with dose. Neither smoking nor alcohol use by fathers increased risks for OC. This study provides further evidence of a possible role of maternal exposure to tobacco smoke and alcohol in the etiology of nonsyndromic oral clefts.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
/
Consumo de Bebidas Alcohólicas
/
Fumar
/
Labio Leporino
/
Fisura del Paladar
/
Consanguinidad
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Child, preschool
/
Femenino
/
Humanos
/
Lactante
/
Masculino
/
Recién Nacido
/
Embarazo
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Braz. oral res
Asunto de la revista:
Odontología
Año:
2009
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of Juiz de Fora/BR
/
Ministry of Health/BR
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