Genome-wide partial correlation analysis of Escherichia coli microarray data
Genet. mol. res. (Online)
;
6(4): 730-742, 2007. ilus, graf
Artículo
en Inglés
| LILACS
| ID: lil-520029
ABSTRACT
Transcriptional control is an essential regulatory mechanism employed by bacteria. Much about transcriptional regulation remains to be discovered, even for the most widely studied bacterium, Escherichia coli. In the present study, we made a genome-wide low-order partial correlation analysis of E. coli microarray data with the purpose of recovering regulatory interactions from transcriptome data. As a result, we produced whole genome transcription factor regulation and co-regulation graphs using the predicted interactions, and we demonstrated how they can be used to investigate regulation and biological function. We concluded that partial correlation analysis can be employed as a method to predict putative regulatory interactions from expression data, as a complementary approach to transcription factor binding site tools and other tools designed to detect co-regulated genes.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Genoma Bacteriano
/
Análisis de Secuencia por Matrices de Oligonucleótidos
/
Escherichia coli
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Genet. mol. res. (Online)
Asunto de la revista:
Biologia Molecular
/
Genética
Año:
2007
Tipo del documento:
Artículo
/
Congreso y conferencia
País de afiliación:
Brasil
/
Italia
Institución/País de afiliación:
Laboratório Nacional de Computação Científica/BR
/
Parco Tecnologico POLARIS/IT
/
Pontifícia Universidade Católica do Rio de Janeiro/BR
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