Protective immunity against Trypanosoma cruzi
Mem. Inst. Oswaldo Cruz
;
104(supl.1): 288-294, July 2009. ilus, graf, tab
Artículo
en Inglés
| LILACS
| ID: lil-520891
ABSTRACT
Upon infection, Trypanosoma cruzi triggers a strong immune response that has both protective and pathological consequences. In this work, several important questions regarding protective immunity are reviewed. Emphasis is placed on recent studies of the important protective role of CD8+ T cells and on previous studies of immunisation of domestic T. cruzi reservoirs that sought to address practical vaccination problems. Research on the maturation of memory cells and studies indicating that the prevalence of T. cruzi-specific T-cell responses and a high frequency of committed CD8+ T cells are associated with better clinical outcomes are also reviewed. Additionally, animal models in which protection was achieved without immunopathological consequences are discussed.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Anticuerpos Antiprotozoarios
/
Vacunas Antiprotozoos
/
Enfermedad de Chagas
Tipo de estudio:
Factores de riesgo
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2009
Tipo del documento:
Artículo
País de afiliación:
Argentina
Institución/País de afiliación:
Universidad Nacional de Salta/AR
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