Asociación de la variante GHRd3 del receptor de la hormona de crecimiento con autoinmunidad en la diabetes tipo 1 / Association of GHRd3 variant of growth hormone receptor gene with autoimmunity in type 1 diabetes
Rev. méd. Chile
; 137(5): 609-616, mayo 2009. tab, graf
Article
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| ID: lil-521862
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BR1.1
ABSTRACT
Background:
Growth Hormone Receptor (GRH) is expressed in the liver, pancreas, stomach and small intestine. A high expression of GHR mRNA in the mucosal gut suggests a possible role of this receptor on digestive and immune functions.Aim:
To investigate the putative effects of the GHRd3 variants on the cytokine profile and distribution of auto-antibodies in children with type 1 diabetes (T1D). Material andMethods:
Unrelated unaffected controls (n =192) and incident cases of children with T1D (n =127) were analyzed for GHRd3 polymorphism, cytokine profile and a panel of auto-antibodies.Results:
The allele frequency for d3 was 24.8 percent in type 1 diabetics and 34.1 percent in controls (p =NS). Among type 1 diabetic children, the carriers of the GHRd3 polymorphism had significantly higher levels of interleukin-lB than homozygous for the wild type genotype (5.7 and 17.7, pg/ml respectively p <0.015). Carriers of d3 variant had a higher frequency of positive anti-insulin antibodies (anti-IAA) than children without this variant (39.6 and 17.7 percent respectively, p <0.01).Conclusions:
The observed frequency of the GHR d3/d3 genotype was comparable to other reports. A relationship between d3 variant and anti-IAA antibodies and interleukin-1ß was observed.Palabras clave
Texto completo:
1
Índice:
LILACS
Asunto principal:
Autoanticuerpos
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Receptores de Somatotropina
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Autoinmunidad
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Citocinas
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Diabetes Mellitus Tipo 1
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Anticuerpos Insulínicos
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Child
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Female
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Humans
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Male
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
2009
Tipo del documento:
Article
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Project document