Transforming growth factor-β1 in congenital ureteropelvic junction obstruction: diagnosis and follow-up
Int. braz. j. urol
;
35(3): 315-325, May-June 2009. tab
Artículo
en Inglés
| LILACS
| ID: lil-523157
ABSTRACT
OBJECTIVE:
To assess the role of transforming growth factor-β1 (TGF-β1) in congenital ureteropelvic junction obstruction at diagnosis and during postoperative follow-up. MATERIAL ANDMETHODS:
We conducted a case-control study including 19 patients with a mean age of 6.7 years and 19 matched controls. All patients presented negative voiding cystourethrography, obstructive diuretic renogram and underwent dismembered pyeloplasty. Urinary TGF-β1 and other markers were measured pre-, intra- and postoperatively.RESULTS:
The mean bladder urine TGF-β1 concentration in obstructed patients prior to pyeloplasty was higher than in controls (92.5 pg/mL ± 16.8 vs. 35.8 pg/mL ± 16.2; p = 0.0001). The mean renal pelvic urine TGF-β1 concentration in the hydronephrotic kidney was higher than in the preoperative bladder urine sample (122.3 pg/mL ± 43.9 vs. 92.5 pg/mL ± 16.8; p = 0.036). Postoperative mean TGF-β1 concentration was significantly lower than preoperative TGF-β1 (48.7 pg/mL ± 13.1 vs. 92.5 pg/mL ± 16.8; p = 0.0001).CONCLUSION:
TGF-β1 is a cytokine leading to renal fibrosis. The measurement of urinary TGF-β1 could become a useful tool for the diagnosis of obstructive hydronephrosis and the evaluation of the parenchyma function status, pre and postoperatively.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Obstrucción Ureteral
/
Factor de Crecimiento Transformador beta1
/
Hidronefrosis
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Int. braz. j. urol
Asunto de la revista:
Urología
Año:
2009
Tipo del documento:
Artículo
País de afiliación:
Argentina
Institución/País de afiliación:
Hospital de Pediatria Dr. J. P. Garrahan/AR
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