The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens
Braz. j. microbiol
;
40(4): 994-1001, Oct.-Dec. 2009. tab
Artículo
en Inglés
| LILACS
| ID: lil-528185
ABSTRACT
Salmonella enterica serovar Gallinarum (SG) is an intracellular pathogen of chickens. To survive, to invade and to multiply in the intestinal tract and intracellularly it depends on its ability to produce energy in anaerobic conditions. The fumarate reductase (frdABCD), dimethyl sulfoxide (DMSO)-trimethylamine N-oxide (TMAO) reductase (dmsABC), and nitrate reductase (narGHIJ) operons in Salmonella Typhimurium (STM) encode enzymes involved in anaerobic respiration to the electron acceptors fumarate, DMSO, TMAO, and nitrate, respectively. They are regulated in response to nitrate and oxygen availability and changes in cell growth rate. In this study mortality rates of chickens challenged with mutants of Salmonella Gallinarum, which were defective in utilising anaerobic electron acceptors, were assessed in comparison to group of bird challenged with wild strain. The greatest degree of attenuation was observed with mutations affecting nitrate reductase (napA, narG) with additional attenuations induced by a mutation affecting fumarate reductase (frdA) and a double mutant (dmsA torC) affecting DMSO and TMAO reductase.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Aves de Corral
/
Infecciones por Salmonella
/
Bacterias Anaerobias
/
Salmonella enterica
/
Activación Enzimática
/
Genes Bacterianos
/
Mutación
Tipo de estudio:
Estudios de evaluación
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. microbiol
Asunto de la revista:
Microbiologia
Año:
2009
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Reino Unido
Institución/País de afiliación:
Universidade Estadual Paulista/BR
/
University of Nottingham/GB
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