Frequency of celiac disease and its serological markers in patients with autoimmune hepatitis
Rev. Ciênc. Méd. Biol. (Impr.)
;
6(2): 175-182, maio-ago. 2007. tab
Artículo
en Inglés
| LILACS, BBO
| ID: lil-529668
ABSTRACT
Transglutaminase (anti-tTG) and anti-endomysial (AEA) antibodies were reported to occur in patients with autoimmune hepatitis (AIH) as well as in subjects with advanced cirrhosis, but the prevalence of celiac disease (CD) in patients with AIH is either negligible or unknown. The frequency of IgA anti-tTG and IgA AEA was determined in 64 patients (54 females, mean age 19[5-67] years ) with AIH diagnosed according to international criteria. Patients with positive or intermediate results for those antibodies were submitted to duodenal biopsy and HLA-DQ2 or DQ8 typing. Anti-tTG and AEA were detected in 6 (9 por cento) and one patient (1.6 por cento) with AIH, respectively. Positive and borderline results for IgA anti-tTG were detected, respectively, in two (3 por cento) and four (6 por cento) patients. Only one patient with HLA-DQ2 and IgA anti-tTG and IgA AEA had CD on duodenal biopsy. Two patients with either positive or borderline results for IgA anti-tTG antibody and HLA-DQ2 had normal histology on duodenal biopsy. IgA anti-tTG antibody and/or AEA were observed in 9% of AIH patients, but CD was confirmed in only one of them. The occurrence of IgA anti-tTG antibody in the other patients could be ascribed to the presence of chronic liver disease or to latent or potential CD.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Pruebas Serológicas
/
Enfermedad Celíaca
/
Hepatitis
Tipo de estudio:
Estudio diagnóstico
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Niño
/
Child, preschool
Idioma:
Inglés
Revista:
Rev. Ciênc. Méd. Biol. (Impr.)
Asunto de la revista:
Biologia
/
Medicina
Año:
2007
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
UFBA/BR
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