Options for clinical trials of pre and post-natal treatments for congenital toxoplasmosis
Mem. Inst. Oswaldo Cruz
;
104(2): 299-304, Mar. 2009. ilus
Artículo
en Inglés
| LILACS
| ID: lil-533521
ABSTRACT
Clinical trials comparing different drug regimens and strategies for the treatment of congenital toxoplasmosis and its clinical manifestations in the liveborn child in different clinical settings should aim at formally evaluating the net benefit of existing treatments and at developing new therapeutic options. Currently, there is no ideal drug for congenital toxoplasmosis; future research should focus on the screening of new active drugs and on their pre-clinical and early clinical development, with a focus on pharmacokinetic/dynamic studies and teratogenicity. For the prenatal treatment of congenital toxoplasmosis, a trial comparing spiramycine to pyrimethamine-sulphadiazine and placebo would allow a formal estimation of the effect of both drugs in infected pregnant women. In newborn children, the net benefit of pyrimethamine-sulphadiazine should also be formally assessed. These trials will be implemented in settings where prenatal screening for Toxoplasma gondii is currently implemented. Trials should be carefully designed to allow for translation to other settings and modelling tools like cost-effectiveness analysis should be used to provide clinicians and founders with the best available evidence to establish recommendations.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Toxoplasmosis Congénita
/
Antiprotozoarios
Tipo de estudio:
Ensayo Clínico Controlado
/
Guía de Práctica Clínica
Límite:
Humanos
/
Recién Nacido
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2009
Tipo del documento:
Artículo
País de afiliación:
Francia
Institución/País de afiliación:
Bordeaux University/FR
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