Alport syndrome: significance of gingival biopsy in the initial diagnosis and periodontal evaluation after renal transplantation
J. appl. oral sci
;
17(6): 623-629, Nov.-Dec. 2009. ilus
Artículo
en Inglés
| LILACS
| ID: lil-534431
ABSTRACT
Alport Syndrome (AS) is an important hereditary disorder affecting the glomerular basement membrane. Diagnosis of AS is based on the presence of hematuric nephropathy, renal failure, hearing loss, ocular abnormalities and changes in the glomerular basement membrane of the lamina densa. The aims of this case report were to show the changes in the gingival tissues in a patient with AS under therapy with cyclosporin-A after renal transplantation and to discuss the possible role of type IV collagen in gingival basal lamina as an alternative approach for the diagnosis of AS. A 20-year-old male patient with AS underwent periodontal therapy including a series of gingivectomy surgeries. Gingival samples obtained during the second surgery were examined histopathologically and by transmission electron microscopy for further pathological examination. Gingivectomy procedures have been performed every 6 months over the last 4 years. The excessive and fibrous gingival enlargements resulted in migration of the anterior teeth, but no alveolar bone loss occurred. This is the first report to demonstrate the possible changes in the gingival tissues caused by AS. It is suggested that gingival biopsy can be an initial diagnostic tool instead of renal or skin biopsies. Proper dental and periodontal care and regular visits to the dentist could provide limited gingival hyperplasia to patients with AS.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Biopsia
/
Trasplante de Riñón
/
Encía
/
Hiperplasia Gingival
/
Nefritis Hereditaria
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
J. appl. oral sci
Asunto de la revista:
Odontología
Año:
2009
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Baskent University/TR
/
Kocaeli University/TR
/
Mustafa Kemal University/TR
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