A comparative study of single-dose treatment of chancroid using thiamphenicol versus Azithromycin
Braz. j. infect. dis
;
13(3): 218-220, June 2009. tab
Artículo
en Inglés
| LILACS
| ID: lil-538523
ABSTRACT
A study was conducted in São Paulo, Brazil, to compare azithromycin with thiamphenicol for the single-dose treatment of chancroid. In all, 54 men with chancroid were tested. The etiology was determined by clinical characterization and direct bacterioscopy with Gram staining. None of the patients had positive serology or dark-field examination indicating active infection with Treponema pallidum. Genital infections due to Neisseria gonorrhoeae and herpes simplex virus were excluded by polymerase chain reaction testing. For 54 patients with chancroid, cure rates with single-dose treatment were 73 percent with azithromycin and 89 percent with thiamphenicol. HIV seropositivity was found to be associated with treatment failure (p=0.001). The treatment failed in all HIV positive patients treated with azithromycin (p=0.002) and this drug should be avoided in these co-infected patients. In the view of the authors, thiamphenicol is the most indicated single-dose regimen for chancroid treatment.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Tianfenicol
/
Chancroide
/
Infecciones Oportunistas Relacionadas con el SIDA
/
Azitromicina
/
Antibacterianos
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Factores de riesgo
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2009
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Santo Amaro University/BR
/
State University of Campinas/BR
/
São Paulo University/BR
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