Pathogenic and opportunistic respiratory bacteria-induced apoptosis
Braz. j. infect. dis
;
13(3): 226-231, June 2009. ilus
Artículo
en Inglés
| LILACS
| ID: lil-538525
ABSTRACT
Several pathogenic or opportunistic bacteria have the ability to either induce or inhibit host cell apoptosis. The capacity to modulate cell pathways that result in the induction or delay of host cell apoptosis is considered to be an important bacterial virulence mechanism. These processes could be mediated by different host cell signaling pathways that are subverted by the bacteria. Pathogens are able to activate apoptotic proteins, such as caspases, or inactivate anti-apoptotic proteins, such as NFkB and the MAPKKs, or even up-regulate the endogenous receptor/ligand system that induces apoptosis, generally when the bacteria are bound to the host cell surface. The bacteria-induced apoptotic or anti-apoptotic processes are often related with the fact that the bacteria acquire the ability to reach the host tissues. However, apoptosis is also considered to be a host defense mechanism against infectious agents. Thus, the apoptosis phenomenon plays a central role in host-pathogen interactions.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Apoptosis
/
Interacciones Huésped-Patógeno
/
Bacterias Gramnegativas
/
Bacterias Grampositivas
Límite:
Humanos
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2009
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
State University of Campinas/BR
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