The Place of protease inhibitors in antiretroviral treatment
Braz. j. infect. dis
;
13(5): 371-374, Oct. 2009. tab, ilus
Artículo
en Inglés
| LILACS
| ID: lil-544993
ABSTRACT
With the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse transcriptase inhibitors-based therapies and ritonavir-boosted protease inhibitors. Both are proven to control viral replication and lead to immunological gain. The choice between a non-nucleoside analog reverse transcriptase inhibitor and a protease inhibitor as a third antiretroviral drug in the therapy should consider factors related to the individual, as well as the inclusion of the best therapy in the patient's daily activities and potential adherence. The protease inhibitor-based therapies showed similar efficacy among the various inhibitors with characteristics concerning the adverse events from each medicine. For the treatment of protease-resistant patients, darunavir and tipranavir showed good efficacy with higher genetic barrier to resistance.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Inhibidores de la Proteasa del VIH
/
Fármacos Anti-VIH
/
Terapia Antirretroviral Altamente Activa
Límite:
Adolescente
/
Adulto
/
Humanos
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2009
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of São Paulo/BR
Similares
MEDLINE
...
LILACS
LIS