Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients
Mem. Inst. Oswaldo Cruz
;
105(3): 326-330, May 2010. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-547305
ABSTRACT
Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with the development of peptic ulcer disease and gastric malignancies. The oral cavity has been implicated as a potential H. pylori reservoir and may therefore be involved in the reinfection of the stomach, which can sometimes occur following treatment of an H. pylori infection. The objectives of this paper were (i) to determine the presence of H. pylori in the oral cavity and (ii) to examine the relationship between oral H. pylori and subsequent gastritis. Gastric biopsies, saliva samples and dental plaques were obtained from 78 dyspeptic adults. DNA was extracted and evaluated for the presence of H. pylori using polymerase chain reaction and Southern blotting methods. Persons with gastritis were frequently positive for H. pylori in their stomachs (p < 0.0001) and there was a statistically significant correlation between the presence of H. pylori in gastric biopsies and the oral cavity (p < 0.0001). Our results suggest a relationship between gastric infection and the presence of this bacterium in the oral cavity. Despite this, H. pylori were present in the oral cavity with variable distribution between saliva and dental plaques, suggesting the existence of a reservoir for the species and a potential association with gastric reinfection.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Saliva
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Placa Dental
/
Dispepsia
/
Gastritis
Tipo de estudio:
Estudio diagnóstico
Límite:
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2010
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
Faculdade de Medicina de Marília/BR
/
Faculdades Integradas de Ourinhos/BR
/
Universidade Federal de São Paulo/BR
/
Universidade do Sagrado Coração/BR
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