Inhibition of peroxidase activity and scavenging of reactive oxygen species by astilbin isolated from Dimorphandra mollis (Fabaceae, Caesalpinioideae)
Biol. Res
;
43(1): 63-74, 2010. ilus, graf
Artículo
en Inglés
| LILACS
| ID: lil-548030
ABSTRACT
Astilbin (5,7,3,4-tetrahydroxy-2,3-dihydroflavonol-3-ß-o-rhamnoside), a flavonoid with a large range of biological activities, was isolated from Dimorphandra mollis, a shrub common to the Brazilian Cerrado. The purpose of this study is to verify the effects of astilbin on myeloperoxidase (MPO) and horseradish peroxidase (HRP), and its antioxidant activity against hypochlorous acid (HOCl) and total antioxidant activity (TAC) by the 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS+). Astilbin inhibited MPO and HRP activities in a concentration-dependent relationship and effectively scavenged HOCl. The TAC by ABTS+ of astilbin (IC50 ~ 20 mM) was higher than that of uric acid, which was used as a positive control. These data demonstrate that astilbin is a potent antioxidant and that it inhibits MPO and HRP activities efficiently.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Extractos Vegetales
/
Depuradores de Radicales Libres
/
Especies Reactivas de Oxígeno
/
Peroxidasa
/
Flavonoles
/
Fabaceae
/
Antioxidantes
Límite:
Humanos
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2010
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
São Paulo State University/BR
/
UFG/BR
/
UNICENTRO/BR
Similares
MEDLINE
...
LILACS
LIS