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Predictors of restenosis after percutaneous coronary intervention using bare-metal stents: a comparison between patients with and without dysglycemia
Lima-Filho, M. O; Figueiredo, G. L; Foss-Freitas, M. C; Foss, M. C; Marin-Neto, J. A.
Afiliación
  • Lima-Filho, M. O; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Divisão de Cardiologia. Ribeirão Preto. BR
  • Figueiredo, G. L; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Divisão de Cardiologia. Ribeirão Preto. BR
  • Foss-Freitas, M. C; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Divisão de Endocrinologia. Ribeirão Preto. BR
  • Foss, M. C; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Divisão de Endocrinologia. Ribeirão Preto. BR
  • Marin-Neto, J. A; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Clínica Médica. Divisão de Cardiologia. Ribeirão Preto. BR
Braz. j. med. biol. res ; 43(6): 572-579, June 2010. ilus, tab
Article en En | LILACS | ID: lil-548266
Biblioteca responsable: BR1.1
ABSTRACT
The objective of this study was to identify intravascular ultrasound (IVUS), angiographic and metabolic parameters related to restenosis in patients with dysglycemia. Seventy consecutive patients (77 lesions) selected according to inclusion and exclusion criteria were evaluated by the oral glucose tolerance test and the determination of insulinemia after a successful percutaneous coronary intervention (PCI) with a bare-metal stent. The degree of insulin resistance was calculated by the homeostasis model assessment of insulin resistance (HOMA-IR). Six-month IVUS and angiogram follow-up were performed. Thirty-nine patients (55.7 percent) had dysglycemia. The restenosis rate in the dysglycemic group was 37.2 vs 23.5 percent in the euglycemic group (P = 0.299). The predictors of restenosis using bivariate analysis were reference vessel diameter (RVD) £2.93 mm (RR = 0.54; 95 percentCI = 0.05-0.78; P = 0.048), stent area (SA) <8.91 mm² (RR = 0.66; 95 percentCI = 0.24-0.85; P = 0.006), stent volume (SV) <119.75 mm³ (RR = 0.74; 95 percentCI = 0.38-0.89; P = 0.0005), HOMA-IR >2.063 (RR = 0.44; 95 percentCI = 0.14-0.64; P = 0.027), and fasting plasma glucose (FPG) ≤108.8 mg/dL (RR = 0.53; 95 percentCI = 0.13-0.75; P = 0.046). SV was an independent predictor of restenosis by multivariable analysis. Dysglycemia is a common clinical condition in patients submitted to PCI. The degree of insulin resistance, FPG, RVD, SA, and SV were correlated with restenosis. SV was inversely correlated with an independent predictor of restenosis in patients treated with a bare-metal stent.
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Texto completo: 1 Índice: LILACS Asunto principal: Angioplastia Coronaria con Balón / Stents / Reestenosis Coronaria / Hiperglucemia Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Braz. j. med. biol. res Asunto de la revista: BIOLOGIA / MEDICINA Año: 2010 Tipo del documento: Article
Texto completo: 1 Índice: LILACS Asunto principal: Angioplastia Coronaria con Balón / Stents / Reestenosis Coronaria / Hiperglucemia Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Braz. j. med. biol. res Asunto de la revista: BIOLOGIA / MEDICINA Año: 2010 Tipo del documento: Article